A Test of Highly Optimized Tolerance Reveals Fragile Cell-Cycle Mechanisms Are Molecular Targets in Clinical Cancer Trials

Robustness, a long-recognized property of living systems, allows function in the face of uncertainty while fragility, i.e., extreme sensitivity, can potentially lead to catastrophic failure following seemingly innocuous perturbations. Carlson and Doyle hypothesized that highly-evolved networks, e.g....

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Detalles Bibliográficos
Autores principales: Nayak, Satyaprakash, Salim, Saniya, Luan, Deyan, Zai, Michael, Varner, Jeffrey D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291571/
https://www.ncbi.nlm.nih.gov/pubmed/18431497
http://dx.doi.org/10.1371/journal.pone.0002016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291571/
https://www.ncbi.nlm.nih.gov/pubmed/18431497
http://dx.doi.org/10.1371/journal.pone.0002016

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