EWS/FLI Mediates Transcriptional Repression via NKX2.2 during Oncogenic Transformation in Ewing's Sarcoma

EWS/FLI is a master regulator of Ewing's sarcoma formation. Gene expression studies in A673 Ewing's sarcoma cells have demonstrated that EWS/FLI downregulates more genes than it upregulates, suggesting that EWS/FLI, and/or its targets, function as transcriptional repressors. One critical E...

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Detalles Bibliográficos
Autores principales: Owen, Leah A., Kowalewski, Ashley A., Lessnick, Stephen L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291578/
https://www.ncbi.nlm.nih.gov/pubmed/18414662
http://dx.doi.org/10.1371/journal.pone.0001965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291578/
https://www.ncbi.nlm.nih.gov/pubmed/18414662
http://dx.doi.org/10.1371/journal.pone.0001965

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