Crystal structures of PI3K-C2α PX domain indicate conformational change associated with ligand binding

BACKGROUND: PX domains have specialized protein structures involved in binding of phosphoinositides (PIs). Through binding to the various PIs PX domains provide site-specific membrane signals to modulate the intracellular localisation and biological activity of effector proteins. Several crystal str...

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Detalles Bibliográficos
Autores principales: Parkinson, Gary N, Vines, David, Driscoll, Paul C, Djordjevic, Snezana
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292188/
https://www.ncbi.nlm.nih.gov/pubmed/18312637
http://dx.doi.org/10.1186/1472-6807-8-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292188/
https://www.ncbi.nlm.nih.gov/pubmed/18312637
http://dx.doi.org/10.1186/1472-6807-8-13

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