Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

Alum (aluminum hydroxide) is the most widely used adjuvant in human vaccines, but the mechanism of its adjuvanticity remains unknown. In vitro studies showed no stimulatory effects on dendritic cells (DCs). In the absence of adjuvant, Ag was taken up by lymph node (LN)–resident DCs that acquired sol...

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Detalles Bibliográficos
Autores principales: Kool, Mirjam, Soullié, Thomas, van Nimwegen, Menno, Willart, Monique A.M., Muskens, Femke, Jung, Steffen, Hoogsteden, Henk C., Hammad, Hamida, Lambrecht, Bart N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292225/
https://www.ncbi.nlm.nih.gov/pubmed/18362170
http://dx.doi.org/10.1084/jem.20071087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292225/
https://www.ncbi.nlm.nih.gov/pubmed/18362170
http://dx.doi.org/10.1084/jem.20071087

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