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Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection

The expression of the prion protein (PrP) is essential for transmissible spongiform encephalopathy (TSE) or prion diseases to occur, but the underlying mechanism of infection remains unresolved. To address the hypothesis that glycosylation of host PrP is a major factor influencing TSE infection, we...

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Detalles Bibliográficos
Autores principales: Tuzi, Nadia L, Cancellotti, Enrico, Baybutt, Herbert, Blackford, Lorraine, Bradford, Barry, Plinston, Chris, Coghill, Anne, Hart, Patricia, Piccardo, Pedro, Barron, Rona M, Manson, Jean C
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292751/
https://www.ncbi.nlm.nih.gov/pubmed/18416605
http://dx.doi.org/10.1371/journal.pbio.0060100