Spontaneous Transient Outward Currents Arise from Microdomains Where BK Channels Are Exposed to a Mean Ca(2+) Concentration on the Order of 10 μM during a Ca(2+) Spark

Ca(2+) sparks are small, localized cytosolic Ca(2+) transients due to Ca(2+) release from sarcoplasmic reticulum through ryanodine receptors. In smooth muscle, Ca(2+) sparks activate large conductance Ca(2+)-activated K(+) channels (BK channels) in the spark microdomain, thus generating spontaneous...

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Detalles Bibliográficos
Autores principales: ZhuGe, Ronghua, Fogarty, Kevin E., Tuft, Richard A., Walsh, John V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311396/
https://www.ncbi.nlm.nih.gov/pubmed/12084772
http://dx.doi.org/10.1085/jgp.20028571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311396/
https://www.ncbi.nlm.nih.gov/pubmed/12084772
http://dx.doi.org/10.1085/jgp.20028571

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