eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

Translation initiation factors have complex functions in cells that are not yet understood. We show that depletion of initiation factor eIF4GI only modestly reduces overall protein synthesis in cells, but phenocopies nutrient starvation or inhibition of protein kinase mTOR, a key nutrient sensor. eI...

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Detalles Bibliográficos
Autores principales: Ramírez-Valle, Francisco, Braunstein, Steve, Zavadil, Jiri, Formenti, Silvia C., Schneider, Robert J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315676/
https://www.ncbi.nlm.nih.gov/pubmed/18426977
http://dx.doi.org/10.1083/jcb.200710215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315676/
https://www.ncbi.nlm.nih.gov/pubmed/18426977
http://dx.doi.org/10.1083/jcb.200710215

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