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eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy
Translation initiation factors have complex functions in cells that are not yet understood. We show that depletion of initiation factor eIF4GI only modestly reduces overall protein synthesis in cells, but phenocopies nutrient starvation or inhibition of protein kinase mTOR, a key nutrient sensor. eI...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315676/ https://www.ncbi.nlm.nih.gov/pubmed/18426977 http://dx.doi.org/10.1083/jcb.200710215 |