Cargando…

SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In Vitro

SARS-coronavirus (SARS-CoV) replication and transcription are mediated by a replication/transcription complex (RTC) of which virus-encoded, non-structural proteins (nsps) are the primary constituents. The 16 SARS-CoV nsps are produced by autoprocessing of two large precursor polyproteins. The RTC is...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Hemert, Martijn J., van den Worm, Sjoerd H. E., Knoops, Kèvin, Mommaas, A. Mieke, Gorbalenya, Alexander E., Snijder, Eric J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322833/ https://www.ncbi.nlm.nih.gov/pubmed/18451981 http://dx.doi.org/10.1371/journal.ppat.1000054

Ejemplares similares

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum
por: Knoops, Kèvin, et al.
Publicado: (2008)

Host Factors in Coronavirus Replication
por: de Wilde, Adriaan H., et al.
Publicado: (2017)

Zn(2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2010)

The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension
por: te Velthuis, Aartjan J.W., et al.
Publicado: (2012)

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2010)

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2011)

Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition
por: Versteeg, Gijs A., et al.
Publicado: (2007)

Membrane heist: Coronavirus host membrane remodeling during replication
por: Zhang, Jingshu, et al.
Publicado: (2020)

Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step
por: Salgado-Benvindo, Clarisse, et al.
Publicado: (2023)

The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein
por: Imbert, Isabelle, et al.
Publicado: (2008)

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design
por: Malone, Brandon, et al.
Publicado: (2021)

Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection
por: Albulescu, Irina C., et al.
Publicado: (2020)

Double-Membrane Vesicles as Platforms for Viral Replication
por: Wolff, Georg, et al.
Publicado: (2020)

R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis
por: Thaler, Melissa, et al.
Publicado: (2023)

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling
por: Treffers, Emmely E., et al.
Publicado: (2023)

Viral cysteine proteinases
por: Gorbalenya, Alexander E., et al.
Publicado: (1996)

Arterivirus Serine Endopeptidase
por: Snijder, Eric J., et al.
Publicado: (2013)

A molecular pore spans the double membrane of the coronavirus replication organelle
por: Wolff, Georg, et al.
Publicado: (2020)

Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property
por: Piotrowski, Yvonne, et al.
Publicado: (2009)

Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle
por: Salgado-Benvindo, Clarisse, et al.
Publicado: (2020)

Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit
por: Slanina, Heiko, et al.
Publicado: (2021)

Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor
por: Willemse, Joost, et al.
Publicado: (2011)

Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based Recombination
por: van den Worm, Sjoerd H. E., et al.
Publicado: (2012)

Coronavirus: epidemiology, genome replication and the interactions with their hosts
por: Shi, Zheng-Li, et al.
Publicado: (2016)

Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles
por: Melia, Charlotte E., et al.
Publicado: (2017)

Arterivirus nsp2 Cysteine Proteinase
por: Kikkert, Marjolein, et al.
Publicado: (2013)

The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture
por: Ogando, Natacha S., et al.
Publicado: (2022)

Structure of the C‐terminal domain of nsp4 from feline coronavirus
por: Manolaridis, Ioannis, et al.
Publicado: (2009)

Arterivirus Nsp1 Modulates the Accumulation of Minus-Strand Templates to Control the Relative Abundance of Viral mRNAs
por: Nedialkova, Danny D., et al.
Publicado: (2010)

Arterivirus Papain-like Proteinase 1β
por: Nedialkova, Danny D., et al.
Publicado: (2013)

Arterivirus Papain-like Proteinase 1α
por: Nedialkova, Danny D., et al.
Publicado: (2013)

Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage
por: Snijder, Eric J., et al.
Publicado: (2003)

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
por: Ogando, Natacha S., et al.
Publicado: (2020)

Nidovirales: Evolving the largest RNA virus genome
por: Gorbalenya, Alexander E., et al.
Publicado: (2006)

Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus
por: Dorobantu, Cristina M., et al.
Publicado: (2015)

The Transformation of Enterovirus Replication Structures: a Three-Dimensional Study of Single- and Double-Membrane Compartments
por: Limpens, Ronald W. A. L., et al.
Publicado: (2011)

O030 Evasion of the OAS-RNase L pathway by murine coronavirus ns2 protein is required for viral replication and hepatitis
por: Jha, B.K., et al.
Publicado: (2012)

Characterization of Synthetic Chikungunya Viruses Based on the Consensus Sequence of Recent E1-226V Isolates
por: Scholte, Florine E. M., et al.
Publicado: (2013)

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment
por: de Wilde, Adriaan H., et al.
Publicado: (2013)

6′-β-Fluoro-Homoaristeromycin and 6′-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1
por: Kovacikova, Kristina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_snj4fdh723kklqh6p8lqletnv2