Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer

ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. Following ligand binding and receptor activation, EGFR is endocytosed and transported to lysosomes where the receptor is degraded...

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Detalles Bibliográficos
Autores principales: Roepstorff, Kirstine, Grøvdal, Lene, Grandal, Michael, Lerdrup, Mads, van Deurs, Bo
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323030/
https://www.ncbi.nlm.nih.gov/pubmed/18288481
http://dx.doi.org/10.1007/s00418-008-0401-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323030/
https://www.ncbi.nlm.nih.gov/pubmed/18288481
http://dx.doi.org/10.1007/s00418-008-0401-3

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