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Housekeeping genes tend to show reduced upstream sequence conservation

BACKGROUND: Understanding the constraints that operate in mammalian gene promoter sequences is of key importance to understand the evolution of gene regulatory networks. The level of promoter conservation varies greatly across orthologous genes, denoting differences in the strength of the evolutiona...

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Detalles Bibliográficos
Autores principales: Farré, Domènec, Bellora, Nicolás, Mularoni, Loris, Messeguer, Xavier, Albà, M Mar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323216/
https://www.ncbi.nlm.nih.gov/pubmed/17626644
http://dx.doi.org/10.1186/gb-2007-8-7-r140