siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P(3)-mTOR signaling pathway as a primary regulator of transferrin uptake

BACKGROUND: Iron uptake via endocytosis of iron-transferrin-transferrin receptor complexes is a rate-limiting step for cell growth, viability and proliferation in tumor cells as well as non-transformed cells such as activated lymphocytes. Signaling pathways that regulate transferrin uptake have not...

Descripción completa

Detalles Bibliográficos
Autores principales: Galvez, Thierry, Teruel, Mary N, Heo, Won Do, Jones, Joshua T, Kim, Man Lyang, Liou, Jen, Myers, Jason W, Meyer, Tobias
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323231/
https://www.ncbi.nlm.nih.gov/pubmed/17640392
http://dx.doi.org/10.1186/gb-2007-8-7-r142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323231/
https://www.ncbi.nlm.nih.gov/pubmed/17640392
http://dx.doi.org/10.1186/gb-2007-8-7-r142

Ejemplares similares