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siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P(3)-mTOR signaling pathway as a primary regulator of transferrin uptake
BACKGROUND: Iron uptake via endocytosis of iron-transferrin-transferrin receptor complexes is a rate-limiting step for cell growth, viability and proliferation in tumor cells as well as non-transformed cells such as activated lymphocytes. Signaling pathways that regulate transferrin uptake have not...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323231/ https://www.ncbi.nlm.nih.gov/pubmed/17640392 http://dx.doi.org/10.1186/gb-2007-8-7-r142 |