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R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation

BACKGROUND: Up to now, two loci have been involved in XX sex-reversal in mammals following loss-of-function mutations, PIS (Polled Intersex Syndrome) in goats and R-spondin1 (RSPO1) in humans. Here, we analyze the possible interaction between these two factors during goat gonad development. Furtherm...

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Detalles Bibliográficos
Autores principales: Kocer, Ayhan, Pinheiro, Iris, Pannetier, Maëlle, Renault, Lauriane, Parma, Pietro, Radi, Orietta, Kim, Kyung-Ah, Camerino, Giovanna, Pailhoux, Eric
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329615/
https://www.ncbi.nlm.nih.gov/pubmed/18384673
http://dx.doi.org/10.1186/1471-213X-8-36