Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction

Toll-like receptors (TLRs) are important regulators of the innate immune response to pathogens, including Mycobacterium leprae, which is recognized by TLR1/2 heterodimers. We previously identified a transmembrane domain polymorphism, TLR1_T1805G, that encodes an isoleucine to serine substitution and...

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Detalles Bibliográficos
Autores principales: Misch, Elizabeth A., Macdonald, Murdo, Ranjit, Chaman, Sapkota, Bishwa R., Wells, Richard D., Siddiqui, M. Ruby, Kaplan, Gilla, Hawn, Thomas R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330092/
https://www.ncbi.nlm.nih.gov/pubmed/18461142
http://dx.doi.org/10.1371/journal.pntd.0000231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330092/
https://www.ncbi.nlm.nih.gov/pubmed/18461142
http://dx.doi.org/10.1371/journal.pntd.0000231

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