Cargando…
Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction
Toll-like receptors (TLRs) are important regulators of the innate immune response to pathogens, including Mycobacterium leprae, which is recognized by TLR1/2 heterodimers. We previously identified a transmembrane domain polymorphism, TLR1_T1805G, that encodes an isoleucine to serine substitution and...
Autores principales: | Misch, Elizabeth A., Macdonald, Murdo, Ranjit, Chaman, Sapkota, Bishwa R., Wells, Richard D., Siddiqui, M. Ruby, Kaplan, Gilla, Hawn, Thomas R. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330092/ https://www.ncbi.nlm.nih.gov/pubmed/18461142 http://dx.doi.org/10.1371/journal.pntd.0000231 |
Ejemplares similares
-
Association of Human TLR1 and TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants
por: Randhawa, April Kaur, et al.
Publicado: (2011) -
Single lesion multibacillary leprosy, a treatment enigma: a case report
por: Sapkota, Bishwa R, et al.
Publicado: (2009) -
Safety and Efficacy Assessment of Two New Leprosy Skin Test Antigens: Randomized Double Blind Clinical Study
por: Rivoire, Becky L., et al.
Publicado: (2014) -
A TLR6 polymorphism is associated with increased risk of Legionnaires’ Disease
por: Misch, Elizabeth Ann, et al.
Publicado: (2013) -
Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6
por: Saini, Chaman, et al.
Publicado: (2016)