Cargando…

Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction

Toll-like receptors (TLRs) are important regulators of the innate immune response to pathogens, including Mycobacterium leprae, which is recognized by TLR1/2 heterodimers. We previously identified a transmembrane domain polymorphism, TLR1_T1805G, that encodes an isoleucine to serine substitution and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Misch, Elizabeth A., Macdonald, Murdo, Ranjit, Chaman, Sapkota, Bishwa R., Wells, Richard D., Siddiqui, M. Ruby, Kaplan, Gilla, Hawn, Thomas R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330092/ https://www.ncbi.nlm.nih.gov/pubmed/18461142 http://dx.doi.org/10.1371/journal.pntd.0000231

Ejemplares similares

Association of Human TLR1 and TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants
por: Randhawa, April Kaur, et al.
Publicado: (2011)

Single lesion multibacillary leprosy, a treatment enigma: a case report
por: Sapkota, Bishwa R, et al.
Publicado: (2009)

Safety and Efficacy Assessment of Two New Leprosy Skin Test Antigens: Randomized Double Blind Clinical Study
por: Rivoire, Becky L., et al.
Publicado: (2014)

A TLR6 polymorphism is associated with increased risk of Legionnaires’ Disease
por: Misch, Elizabeth Ann, et al.
Publicado: (2013)

Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6
por: Saini, Chaman, et al.
Publicado: (2016)

Adverse reactions in leprosy patients who underwent dapsone multidrug therapy: a retrospective study
por: Guragain, Sanjeev, et al.
Publicado: (2017)

Using Omics to Study Leprosy, Tuberculosis, and Other Mycobacterial Diseases
por: Ahamad, Naseem, et al.
Publicado: (2022)

Editorial: Using omics to study leprosy, tuberculosis, and other mycobacterial diseases
por: de Macedo, Cristiana Santos, et al.
Publicado: (2022)

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth
por: Fletcher, Helen A, et al.
Publicado: (2009)

Genetic Variation in TLR Genes in Ugandan and South African Populations and Comparison with HapMap Data
por: Baker, Allison R., et al.
Publicado: (2012)

Subclinical leprosy manifesting as a reversal reaction after LHRH agonist administration
por: Carmo, R.L.M.L., et al.
Publicado: (2018)

Association of GT microsatellite polymorphism in TLR 2 gene with leprosy
por: Suryadevara, NC, et al.
Publicado: (2012)

Gene Set Signature of Reversal Reaction Type I in Leprosy Patients
por: Orlova, Marianna, et al.
Publicado: (2013)

Differential Expression of IFN-γ, IL-10, TLR1, and TLR2 and Their Potential Effects on Downgrading Leprosy Reaction and Erythema Nodosum Leprosum
por: Antunes, Douglas Eulálio, et al.
Publicado: (2019)

The TLR1 gene is associated with higher protection from leprosy in women
por: Alvarenga Niitsuma, Eyleen Nabyla, et al.
Publicado: (2018)

Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man
por: Fu, Xi’an, et al.
Publicado: (2015)

Differential Dermal Expression of CCL17 and CCL18 in Tuberculoid and Lepromatous Leprosy
por: Berrington, William R., et al.
Publicado: (2014)

Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum
por: Amorim, Francianne M., et al.
Publicado: (2019)

Increase in TGF-β Secreting CD4(+)CD25(+) FOXP3(+) T Regulatory Cells in Anergic Lepromatous Leprosy Patients
por: Saini, Chaman, et al.
Publicado: (2014)

Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy
por: de Mattos Barbosa, Mayara Garcia, et al.
Publicado: (2018)

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages
por: Oldenburg, Reid, et al.
Publicado: (2018)

Filarial Bursitis Complicating Leprosy Reaction
por: Verma, Ghanshyam K, et al.
Publicado: (2021)

Comparing the Clinical and Histological Diagnosis of Leprosy and Leprosy Reactions in the INFIR Cohort of Indian Patients with Multibacillary Leprosy
por: Lockwood, Diana N. J., et al.
Publicado: (2012)

CD36 deficiency attenuates experimental mycobacterial infection
por: Hawkes, Michael, et al.
Publicado: (2010)

A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction?
por: Miyashiro, Denis, et al.
Publicado: (2017)

Opening a Can of Worms: Leprosy Reactions and Complicit Soil-Transmitted Helminths
por: Hagge, Deanna A., et al.
Publicado: (2017)

Elevated IL-6R on CD4(+) T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions
por: Saini, Chaman, et al.
Publicado: (2020)

CD4+ Th17 Cells Discriminate Clinical Types and Constitute a Third Subset of Non Th1, Non Th2 T Cells in Human Leprosy
por: Saini, Chaman, et al.
Publicado: (2013)

One Case of Tuberculosis-Like Leprosy with a Type I Leprosy Reaction
por: Li, Jie, et al.
Publicado: (2023)

Association of IL-10 Gene Polymorphism With IL-10 Secretion by CD4 and T Regulatory Cells in Human Leprosy
por: Tarique, Mohammad, et al.
Publicado: (2020)

Evaluating Cross-Applicability of Weed Detection Models Across Different Crops in Similar Production Environments
por: Sapkota, Bishwa B., et al.
Publicado: (2022)

Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2
Publicado: (1983)

Profiling mycobacterial communities in pulmonary nontuberculous mycobacterial disease
por: Cowman, Steven A., et al.
Publicado: (2018)

Integration of Leprosy Elimination into Primary Health Care in Orissa, India
por: Siddiqui, M. Ruby, et al.
Publicado: (2009)

Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes
por: Rêgo, Jamile Leão, et al.
Publicado: (2018)

Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction
por: Teles, Rosane M. B., et al.
Publicado: (2019)

THE COMPLEMENT FIXATION REACTION AS APPLIED TO LEPROSY
por: Lewis, Paul A., et al.
Publicado: (1923)

Electrophysiological Study of Nerves in Type-II Reaction in Leprosy
por: Singh, Santosh Kumar, et al.
Publicado: (2017)

Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy
por: Gonzalez-Orozco, Maria, et al.
Publicado: (2022)

Molecular assessment of mycobacterial burden in the treatment of nontuberculous mycobacterial disease
por: Ellis, Huw C., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kardki34f5b8o3bhgdhh8unaqj