Activation of p38MAPK Contributes to Expanded Polyglutamine-Induced Cytotoxicity

BACKGROUND: The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. METHODOLOGIES/PRINCIPAL FINDINGS: Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p...

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Detalles Bibliográficos
Autores principales: Tsirigotis, Maria, Baldwin, R. Mitchell, Tang, Matthew Y., Lorimer, Ian A. J., Gray, Douglas A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330164/
https://www.ncbi.nlm.nih.gov/pubmed/18461158
http://dx.doi.org/10.1371/journal.pone.0002130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330164/
https://www.ncbi.nlm.nih.gov/pubmed/18461158
http://dx.doi.org/10.1371/journal.pone.0002130

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