Unexpected A-form formation of 4′-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease resistance

Fully modified 4′-thioDNA, an oligonucleotide only comprising 2′-deoxy-4′-thionucleosides, exhibited resistance to an endonuclease, in addition to preferable hybridization with RNA. Therefore, 4′-thioDNA is promising for application as a functional oligonucleotide. Fully modified 4′-thioDNA was foun...

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Detalles Bibliográficos
Autores principales: Matsugami, Akimasa, Ohyama, Takako, Inada, Masashi, Inoue, Naonori, Minakawa, Noriaki, Matsuda, Akira, Katahira, Masato
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330235/
https://www.ncbi.nlm.nih.gov/pubmed/18252770
http://dx.doi.org/10.1093/nar/gkn011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330235/
https://www.ncbi.nlm.nih.gov/pubmed/18252770
http://dx.doi.org/10.1093/nar/gkn011

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