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An Extracellular Cu(2+) Binding Site in the Voltage Sensor of BK and Shaker Potassium Channels
Copper is an essential trace element that may serve as a signaling molecule in the nervous system. Here we show that extracellular Cu(2+) is a potent inhibitor of BK and Shaker K(+) channels. At low micromolar concentrations, Cu(2+) rapidly and reversibly reduces macrosocopic K(+) conductance (G(K))...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346571/ https://www.ncbi.nlm.nih.gov/pubmed/18443360 http://dx.doi.org/10.1085/jgp.200809980 |