Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice

The sphingolipid ceramide is intimately involved in the growth, differentiation, senescence, and death of normal and cancerous cells. Mitochondria are increasingly appreciated to play a key role in ceramide-induced cell death. Recent work showed the C16-pyridinium ceramide analogue LCL-30 to induce...

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Detalles Bibliográficos
Autores principales: Dahm, F, Bielawska, A, Nocito, A, Georgiev, P, Szulc, Z M, Bielawski, J, Jochum, W, Dindo, D, Hannun, Y A, Clavien, P-A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359695/
https://www.ncbi.nlm.nih.gov/pubmed/18026195
http://dx.doi.org/10.1038/sj.bjc.6604099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359695/
https://www.ncbi.nlm.nih.gov/pubmed/18026195
http://dx.doi.org/10.1038/sj.bjc.6604099

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