The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish

BACKGROUND: Key molecules involved in notochord differentiation and function have been identified through genetic analysis in zebrafish and mice, but MEK1 and 2 have so far not been implicated in this process due to early lethality (Mek1-/-) and functional redundancy (Mek2-/-) in the knockout animal...

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Detalles Bibliográficos
Autores principales: Hawkins, Thomas A, Cavodeassi, Florencia, Erdélyi, Ferenc, Szabó, Gábor, Lele, Zsolt
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359734/
https://www.ncbi.nlm.nih.gov/pubmed/18419805
http://dx.doi.org/10.1186/1471-213X-8-42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359734/
https://www.ncbi.nlm.nih.gov/pubmed/18419805
http://dx.doi.org/10.1186/1471-213X-8-42

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