Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties

A wild-type (wt) p53 gene characterizes thyroid tumors, except for the rare anaplastic histotype. Because p53 inactivation is a prerequisite for tumor development, alterations of p53 regulators represent an alternative way to impair p53 function. Indeed, murine double minute 2 (MDM2), the main p53 n...

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Detalles Bibliográficos
Autores principales: Prodosmo, Andrea, Giglio, Simona, Moretti, Sonia, Mancini, Francesca, Barbi, Flavia, Avenia, Nicola, Di Conza, Giusy, Schünemann, Holger J., Pistola, Lorenza, Ludovini, Vienna, Sacchi, Ada, Pontecorvi, Alfredo, Puxeddu, Efisio, Moretti, Fabiola
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359832/
https://www.ncbi.nlm.nih.gov/pubmed/18335186
http://dx.doi.org/10.1007/s00109-008-0322-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359832/
https://www.ncbi.nlm.nih.gov/pubmed/18335186
http://dx.doi.org/10.1007/s00109-008-0322-6

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