Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer

The cancer risk is unknown for those families in which a microsatellite instable tumour is neither explained by MLH1 promoter methylation nor by a germline mutation in a mismatch repair (MMR) gene. Such information is essential for genetic counselling. Families suspected of Lynch syndrome (n=614) we...

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Detalles Bibliográficos
Autores principales: Overbeek, L I H, Kets, C M, Hebeda, K M, Bodmer, D, der Looij, E van, Willems, R, Goossens, M, Arts, N, Brunner, H G, van Krieken, J H J M, Hoogerbrugge, N, Ligtenberg, M J L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359954/
https://www.ncbi.nlm.nih.gov/pubmed/17453009
http://dx.doi.org/10.1038/sj.bjc.6603754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359954/
https://www.ncbi.nlm.nih.gov/pubmed/17453009
http://dx.doi.org/10.1038/sj.bjc.6603754

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