Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts

Hypoxia is closely associated with the radioresistance of tumours; therefore, targeting hypoxic areas is very important for cancer therapy. The aim of this study is to establish such a targeting strategy by applying a bacterial cytosine deaminase (BCD)/5-fluorocytosine (5-FC) gene therapy system and...

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Detalles Bibliográficos
Autores principales: Liu, J, Harada, H, Ogura, M, Shibata, T, Hiraoka, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359966/
https://www.ncbi.nlm.nih.gov/pubmed/17519901
http://dx.doi.org/10.1038/sj.bjc.6603812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359966/
https://www.ncbi.nlm.nih.gov/pubmed/17519901
http://dx.doi.org/10.1038/sj.bjc.6603812

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