Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, wxc-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases

The urokinase plasminogen activator (u-PA) is intimately associated with tumour invasion and metastases. Surgery facilitates accelerated metastatic tumour growth in murine models, a phenomenon related to elevated perioperative bacterial lipopolysaccaride (LPS) and inflammatory cytokine levels. The o...

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Detalles Bibliográficos
Autores principales: Killeen, S D, Andrews, E J, Wang, J H, Wu, T, Schmalix, W, Muehlenweg, B, Redmond, H P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360002/
https://www.ncbi.nlm.nih.gov/pubmed/17242699
http://dx.doi.org/10.1038/sj.bjc.6603550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360002/
https://www.ncbi.nlm.nih.gov/pubmed/17242699
http://dx.doi.org/10.1038/sj.bjc.6603550

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