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Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, wxc-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases

The urokinase plasminogen activator (u-PA) is intimately associated with tumour invasion and metastases. Surgery facilitates accelerated metastatic tumour growth in murine models, a phenomenon related to elevated perioperative bacterial lipopolysaccaride (LPS) and inflammatory cytokine levels. The o...

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Detalles Bibliográficos
Autores principales:	Killeen, S D, Andrews, E J, Wang, J H, Wu, T, Schmalix, W, Muehlenweg, B, Redmond, H P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360002/ https://www.ncbi.nlm.nih.gov/pubmed/17242699 http://dx.doi.org/10.1038/sj.bjc.6603550

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