A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells

MBD4 binds to methylated DNA and acts as a thymine DNA glycosylase in base excision repair. Deficiency of MBD4 in mice enhances mutation at CpG sites and alters apoptosis in response to DNA damage, but does not increase tumorigenesis in mismatch repair-deficient mice. However, in humans, frameshift...

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Detalles Bibliográficos
Autores principales: Bader, S A, Walker, M, Harrison, D J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360052/
https://www.ncbi.nlm.nih.gov/pubmed/17285135
http://dx.doi.org/10.1038/sj.bjc.6603592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360052/
https://www.ncbi.nlm.nih.gov/pubmed/17285135
http://dx.doi.org/10.1038/sj.bjc.6603592

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