Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction

The cytotoxic effects of anticancer immune cells are mediated by perforin/granzyme-B, Fas ligand and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), and therefore depend on intact apoptotic responses in target tumour cells. As killing by all three of these mechanisms is blocked by...

Descripción completa

Detalles Bibliográficos
Autores principales: Lickliter, J D, Cox, J, McCarron, J, Martinez, N R, Schmidt, C W, Lin, H, Nieda, M, Nicol, A J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360057/
https://www.ncbi.nlm.nih.gov/pubmed/17311012
http://dx.doi.org/10.1038/sj.bjc.6603599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360057/
https://www.ncbi.nlm.nih.gov/pubmed/17311012
http://dx.doi.org/10.1038/sj.bjc.6603599

Ejemplares similares