Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival

Bmi-1 is a polycomb group protein that was identified as c-myc cooperating oncogene in murine lymphomagenesis. The current study was undertaken to determine the role of Bmi-1 in human oral carcinogenesis. Bmi-1 protein and RNA expression levels were markedly enhanced in the cells of oral squamous ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, M K, Kim, R H, Kim, S J, Yip, F K, Shin, K-H, Dimri, G P, Christensen, R, Han, T, Park, N-H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360223/
https://www.ncbi.nlm.nih.gov/pubmed/17179983
http://dx.doi.org/10.1038/sj.bjc.6603529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360223/
https://www.ncbi.nlm.nih.gov/pubmed/17179983
http://dx.doi.org/10.1038/sj.bjc.6603529

Ejemplares similares