Cancer risks among BRCA1 and BRCA2 mutation carriers

BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unid...

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Detalles Bibliográficos
Autores principales: Levy-Lahad, E, Friedman, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360226/
https://www.ncbi.nlm.nih.gov/pubmed/17213823
http://dx.doi.org/10.1038/sj.bjc.6603535
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author Levy-Lahad, E
Friedman, E
author_facet Levy-Lahad, E
Friedman, E
author_sort Levy-Lahad, E
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description BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.
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spelling pubmed-23602262009-09-10 Cancer risks among BRCA1 and BRCA2 mutation carriers Levy-Lahad, E Friedman, E Br J Cancer Minireview BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction. Nature Publishing Group 2007-01-15 2007-01-09 /pmc/articles/PMC2360226/ /pubmed/17213823 http://dx.doi.org/10.1038/sj.bjc.6603535 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Levy-Lahad, E
Friedman, E
Cancer risks among BRCA1 and BRCA2 mutation carriers
title Cancer risks among BRCA1 and BRCA2 mutation carriers
title_full Cancer risks among BRCA1 and BRCA2 mutation carriers
title_fullStr Cancer risks among BRCA1 and BRCA2 mutation carriers
title_full_unstemmed Cancer risks among BRCA1 and BRCA2 mutation carriers
title_short Cancer risks among BRCA1 and BRCA2 mutation carriers
title_sort cancer risks among brca1 and brca2 mutation carriers
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360226/
https://www.ncbi.nlm.nih.gov/pubmed/17213823
http://dx.doi.org/10.1038/sj.bjc.6603535
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