Development of IFN-γ resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells

The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. Here we studied the evolution of an IFN-resistant state in vitro using melanoma cell lines. We found that the cells became less sensitive to antiproliferative effect of IFN-γ after prolonged cultivation enabling us to...

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Detalles Bibliográficos
Autores principales: Fojtova, M, Boudny, V, Kovarik, A, Lauerova, L, Adamkova, L, Souckova, K, Jarkovsky, J, Kovarik, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360293/
https://www.ncbi.nlm.nih.gov/pubmed/17579625
http://dx.doi.org/10.1038/sj.bjc.6603849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360293/
https://www.ncbi.nlm.nih.gov/pubmed/17579625
http://dx.doi.org/10.1038/sj.bjc.6603849

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