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Development of IFN-γ resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells
The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. Here we studied the evolution of an IFN-resistant state in vitro using melanoma cell lines. We found that the cells became less sensitive to antiproliferative effect of IFN-γ after prolonged cultivation enabling us to...
Autores principales: | Fojtova, M, Boudny, V, Kovarik, A, Lauerova, L, Adamkova, L, Souckova, K, Jarkovsky, J, Kovarik, J |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360293/ https://www.ncbi.nlm.nih.gov/pubmed/17579625 http://dx.doi.org/10.1038/sj.bjc.6603849 |
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