Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion

The c-MET receptor can be overexpressed, amplified, or mutated in solid tumours including small cell lung cancer (SCLC). In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine k...

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Detalles Bibliográficos
Autores principales: Ma, P C, Tretiakova, M S, Nallasura, V, Jagadeeswaran, R, Husain, A N, Salgia, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360323/
https://www.ncbi.nlm.nih.gov/pubmed/17667909
http://dx.doi.org/10.1038/sj.bjc.6603884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360323/
https://www.ncbi.nlm.nih.gov/pubmed/17667909
http://dx.doi.org/10.1038/sj.bjc.6603884

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