The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model

Tumour drug-resistant ABCB1 gene expression is regulated at the chromatin level through epigenetic mechanisms. We examined the effects of the histone deacetylase inhibitor trichostatin A (TSA) on ABCB1 gene expression in small cell lung carcinoma (SCLC) drug-sensitive (H69WT) or etoposide-resistant...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Khoury, V, Breuzard, G, Fourré, N, Dufer, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360351/
https://www.ncbi.nlm.nih.gov/pubmed/17667922
http://dx.doi.org/10.1038/sj.bjc.6603914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360351/
https://www.ncbi.nlm.nih.gov/pubmed/17667922
http://dx.doi.org/10.1038/sj.bjc.6603914

Ejemplares similares