Identification of gene polymorphisms of human DNA topoisomerase I in the National Cancer Institute panel of human tumour cell lines

Topoisomerase 1 (Top1), a nuclear enzyme involved in DNA relaxation, is the target of several anticancer drugs. TOP1 mutations occur in camptothecin-resistant tumour cell lines. We explored, in the NCI panel of 60 human tumour cell lines, whether polymorphic variations in the TOP1 gene could explain...

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Detalles Bibliográficos
Autores principales: Moisan, F, Longy, M, Robert, J, Le Morvan, V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360536/
https://www.ncbi.nlm.nih.gov/pubmed/16983402
http://dx.doi.org/10.1038/sj.bjc.6603361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360536/
https://www.ncbi.nlm.nih.gov/pubmed/16983402
http://dx.doi.org/10.1038/sj.bjc.6603361

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