Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells

Resistance to antiepidermal growth factor (EGFR) strategies is an emerging clinical problem. Using human colorectal cancer (CRC) cells, we evaluated the involvement of the insulin receptor isoform-A (InsR-A) in de novo resistance to gefitinib, an EGFR tyrosine kinase inhibitor. Challenging the EGFR...

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Detalles Bibliográficos
Autores principales: Jones, H E, Gee, J M W, Barrow, D, Tonge, D, Holloway, B, Nicholson, R I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360620/
https://www.ncbi.nlm.nih.gov/pubmed/16819546
http://dx.doi.org/10.1038/sj.bjc.6603237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360620/
https://www.ncbi.nlm.nih.gov/pubmed/16819546
http://dx.doi.org/10.1038/sj.bjc.6603237

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