Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers

We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all...

Descripción completa

Detalles Bibliográficos
Autores principales: Clarke, C L, Sandle, J, Jones, A A, Sofronis, A, Patani, N R, Lakhani, S R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360661/
https://www.ncbi.nlm.nih.gov/pubmed/16880780
http://dx.doi.org/10.1038/sj.bjc.6603298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360661/
https://www.ncbi.nlm.nih.gov/pubmed/16880780
http://dx.doi.org/10.1038/sj.bjc.6603298

Ejemplares similares