Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia

BRCA1 plays a pivotal role in the repair of DNA damage, especially following chemotherapy and ionising radiation. We were interested in the regulation of BRCA1 expression in acute myeloid leukaemia (AML), in particular in therapy-related forms (t-AML). Using real-time PCR and Western blot, we found...

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Detalles Bibliográficos
Autores principales: Scardocci, A, Guidi, F, D'Alo', F, Gumiero, D, Fabiani, E, DiRuscio, A, Martini, M, Larocca, L M, Zollino, M, Hohaus, S, Leone, G, Voso, M T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360697/
https://www.ncbi.nlm.nih.gov/pubmed/17047656
http://dx.doi.org/10.1038/sj.bjc.6603392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360697/
https://www.ncbi.nlm.nih.gov/pubmed/17047656
http://dx.doi.org/10.1038/sj.bjc.6603392

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