Novel heteroduplex method using small cytology specimens with a remarkably high success rate for analysing EGFR gene mutations with a significant correlation to gefitinib efficacy in non-small-cell lung cancer

We conducted a feasibility study to examine whether small numbers of cancer cells could be utilised for analysis of the EGFR gene status using the loop-hybrid mobility shift assay, which is a modified heteroduplex technique. Cytology specimens obtained by transbronchial abrasion were successfully us...

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Detalles Bibliográficos
Autores principales: Oshita, F, Matsukuma, S, Yoshihara, M, Sakuma, Y, Ohgane, N, Kameda, Y, Saito, H, Yamada, K, Tsuchiya, E, Miyagi, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360725/
https://www.ncbi.nlm.nih.gov/pubmed/17047654
http://dx.doi.org/10.1038/sj.bjc.6603396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360725/
https://www.ncbi.nlm.nih.gov/pubmed/17047654
http://dx.doi.org/10.1038/sj.bjc.6603396

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