Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells

The antimetabolite mercaptopurine (MP) is widely used to treat childhood acute lymphoblastic leukaemia (ALL). To study the dynamics of MP on the cell cycle, we incubated human T-cell leukaemia cell lines (Molt-4 sensitive and resistant subline and P12 resistant) with 10 μM MP and measured total cell...

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Detalles Bibliográficos
Autores principales: Panetta, J C, Evans, W E, Cheok, M H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361089/
https://www.ncbi.nlm.nih.gov/pubmed/16333308
http://dx.doi.org/10.1038/sj.bjc.6602893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361089/
https://www.ncbi.nlm.nih.gov/pubmed/16333308
http://dx.doi.org/10.1038/sj.bjc.6602893

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