TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt

The majority of leukaemic cells are resistant to apoptosis induced by tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). Here, we show that sublethal concentrations of arsenic trioxide (ATO) specifically enhanced TRAIL-induced apoptosis in leukaemic but not in other tumour cell lines....

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Detalles Bibliográficos
Autores principales: Szegezdi, E, Cahill, S, Meyer, M, O'Dwyer, M, Samali, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361137/
https://www.ncbi.nlm.nih.gov/pubmed/16434995
http://dx.doi.org/10.1038/sj.bjc.6602954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361137/
https://www.ncbi.nlm.nih.gov/pubmed/16434995
http://dx.doi.org/10.1038/sj.bjc.6602954

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