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The telomeric PARP, tankyrases, as targets for cancer therapy

The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase 1 modulates telomerase inhibition in human cancer c...

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Detalles Bibliográficos
Autor principal: Seimiya, H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361147/
https://www.ncbi.nlm.nih.gov/pubmed/16421589
http://dx.doi.org/10.1038/sj.bjc.6602951