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The telomeric PARP, tankyrases, as targets for cancer therapy
The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase 1 modulates telomerase inhibition in human cancer c...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361147/ https://www.ncbi.nlm.nih.gov/pubmed/16421589 http://dx.doi.org/10.1038/sj.bjc.6602951 |
| Sumario: | The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase 1 modulates telomerase inhibition in human cancer cells and is reviewed in this report as a potential telomere-directed anticancer target. |
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