DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer

The CpG-island methylator phenotype (CIMP+) in colorectal cancer (CRC) is characterised by frequent hypermethylation of promoter regions in tumour suppressor genes. Low level methylation of some CpG islands is also seen in the normal colonic mucosa and increases with age; however, it is still unclea...

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Detalles Bibliográficos
Autores principales: Kawakami, K, Ruszkiewicz, A, Bennett, G, Moore, J, Grieu, F, Watanabe, G, Iacopetta, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361181/
https://www.ncbi.nlm.nih.gov/pubmed/16421593
http://dx.doi.org/10.1038/sj.bjc.6602940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361181/
https://www.ncbi.nlm.nih.gov/pubmed/16421593
http://dx.doi.org/10.1038/sj.bjc.6602940

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