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Epigenetics as a mechanism driving polygenic clinical drug resistance

Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development. It is increasingly recognised that such epimutations may occur at a much higher frequency than gene mutation and therefore have a greater impact on sele...

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Detalles Bibliográficos
Autores principales: Glasspool, R M, Teodoridis, J M, Brown, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361257/
https://www.ncbi.nlm.nih.gov/pubmed/16495912
http://dx.doi.org/10.1038/sj.bjc.6603024