Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01

Histone deacetylase inhibitors (HDACIs) are novel anticancer agents with potent cytotoxicity against a wide range of malignancies. We have previously demonstrated that either Calphostin C (CC) (a protein kinase C (PKC) inhibitor) or Parthenolide (an NF-κB inhibitor) abrogates HDACI-induced transcrip...

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Detalles Bibliográficos
Autores principales: Yeow, W-S, Ziauddin, M F, Maxhimer, J B, Shamimi-Noori, S, Baras, A, Chua, A, Schrump, D S, Nguyen, D M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361280/
https://www.ncbi.nlm.nih.gov/pubmed/16705314
http://dx.doi.org/10.1038/sj.bjc.6603132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361280/
https://www.ncbi.nlm.nih.gov/pubmed/16705314
http://dx.doi.org/10.1038/sj.bjc.6603132

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