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Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma
Overexpression of the transcriptional activator β-catenin, mostly owing to loss-of-function mutations of the adenomatous polyposis coli (APC) tumour suppressor gene, is crucial for the initiation and progression of human colorectal carcinogenesis. Securin is a regulator of chromosome separation and...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361298/ https://www.ncbi.nlm.nih.gov/pubmed/16705313 http://dx.doi.org/10.1038/sj.bjc.6603155 |
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author | Hlubek, F Pfeiffer, S Budczies, J Spaderna, S Jung, A Kirchner, T Brabletz, T |
author_facet | Hlubek, F Pfeiffer, S Budczies, J Spaderna, S Jung, A Kirchner, T Brabletz, T |
author_sort | Hlubek, F |
collection | PubMed |
description | Overexpression of the transcriptional activator β-catenin, mostly owing to loss-of-function mutations of the adenomatous polyposis coli (APC) tumour suppressor gene, is crucial for the initiation and progression of human colorectal carcinogenesis. Securin is a regulator of chromosome separation and its overexpression has been shown to be involved in different tumour-promoting processes, like transformation, hyperproliferation and angiogenesis, and correlates with tumour cell invasion. However, the molecular mechanism leading to securin overexpression in human colorectal cancer is unknown. Here we show a correlated high expression of β-catenin and securin (hPTTG1) in colorectal adenomas and carcinomas and further demonstrate that securin is a target of β-catenin transcriptional activation. This implies that deregulation of the β-catenin/T-cell factor-signalling pathway leads to overexpression of securin in human colorectal cancer, which subsequently may contribute to tumour progression. |
format | Text |
id | pubmed-2361298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23612982009-09-10 Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma Hlubek, F Pfeiffer, S Budczies, J Spaderna, S Jung, A Kirchner, T Brabletz, T Br J Cancer Molecular Diagnostics Overexpression of the transcriptional activator β-catenin, mostly owing to loss-of-function mutations of the adenomatous polyposis coli (APC) tumour suppressor gene, is crucial for the initiation and progression of human colorectal carcinogenesis. Securin is a regulator of chromosome separation and its overexpression has been shown to be involved in different tumour-promoting processes, like transformation, hyperproliferation and angiogenesis, and correlates with tumour cell invasion. However, the molecular mechanism leading to securin overexpression in human colorectal cancer is unknown. Here we show a correlated high expression of β-catenin and securin (hPTTG1) in colorectal adenomas and carcinomas and further demonstrate that securin is a target of β-catenin transcriptional activation. This implies that deregulation of the β-catenin/T-cell factor-signalling pathway leads to overexpression of securin in human colorectal cancer, which subsequently may contribute to tumour progression. Nature Publishing Group 2006-06-05 2006-05-16 /pmc/articles/PMC2361298/ /pubmed/16705313 http://dx.doi.org/10.1038/sj.bjc.6603155 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Molecular Diagnostics Hlubek, F Pfeiffer, S Budczies, J Spaderna, S Jung, A Kirchner, T Brabletz, T Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma |
title | Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma |
title_full | Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma |
title_fullStr | Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma |
title_full_unstemmed | Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma |
title_short | Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma |
title_sort | securin (hpttg1) expression is regulated by β-catenin/tcf in human colorectal carcinoma |
topic | Molecular Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361298/ https://www.ncbi.nlm.nih.gov/pubmed/16705313 http://dx.doi.org/10.1038/sj.bjc.6603155 |
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