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Inhibition of endosomal sequestration of basic anticancer drugs: influence on cytotoxicity and tissue penetration
The basic drugs doxorubicin and mitoxantrone are known to be concentrated in acidic endosomes of cells. Here, we address the hypotheses that raising endosomal pH with the modifying agents chloroquine, omeprazole or bafilomycin A might decrease sequestration of anticancer drugs in endosomes, thereby...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361369/ https://www.ncbi.nlm.nih.gov/pubmed/16495919 http://dx.doi.org/10.1038/sj.bjc.6603010 |