Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells

Glioblastoma is characterised by invasive growth and a high degree of radioresistance. Survivin, a regulator of chromosome segregation, is highly expressed and known to induce radioresistance in human gliomas. In this study, we examined the effect of survivin suppression on radiosensitivity in malig...

Descripción completa

Detalles Bibliográficos
Autores principales: Saito, T, Hama, S, Izumi, H, Yamasaki, F, Kajiwara, Y, Matsuura, S, Morishima, K, Hidaka, T, Shrestha, P, Sugiyama, K, Kurisu, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361434/
https://www.ncbi.nlm.nih.gov/pubmed/18195712
http://dx.doi.org/10.1038/sj.bjc.6604160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361434/
https://www.ncbi.nlm.nih.gov/pubmed/18195712
http://dx.doi.org/10.1038/sj.bjc.6604160

Ejemplares similares