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Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells

Glioblastoma is characterised by invasive growth and a high degree of radioresistance. Survivin, a regulator of chromosome segregation, is highly expressed and known to induce radioresistance in human gliomas. In this study, we examined the effect of survivin suppression on radiosensitivity in malig...

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Detalles Bibliográficos
Autores principales:	Saito, T, Hama, S, Izumi, H, Yamasaki, F, Kajiwara, Y, Matsuura, S, Morishima, K, Hidaka, T, Shrestha, P, Sugiyama, K, Kurisu, K
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361434/ https://www.ncbi.nlm.nih.gov/pubmed/18195712 http://dx.doi.org/10.1038/sj.bjc.6604160

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